Details

Autor(en) / Beteiligte

• Han, J.D.J
• Bertin, N
• Hao, T
• Goldberg, D.S
• Berriz, G.F
• Zhang, L.V
• Dupuy, D
• Walhout, A.J.M
• Cusick, M.E
• Roth, F.P

Titel

Evidence for dynamically organized modularity in the yeast protein-protein interaction network

Ist Teil von

• Nature, 2004-07, Vol.430 (6995), p.88-93

Ort / Verlag

London: Nature Publishing

Erscheinungsjahr

2004

Link zum Volltext

Quelle

Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• In apparently scale-free protein-protein interaction networks, or 'interactome' networks, most proteins interact with few partners, whereas a small but significant proportion of proteins, the 'hubs', interact with many partners. Both biological and non-biological scale-free networks are particularly resistant to random node removal but are extremely sensitive to the targeted removal of hubs. A link between the potential scale-free topology of interactome networks and genetic robustness seems to exist, because knockouts of yeast genes encoding hubs are approximately threefold more likely to confer lethality than those of non-hubs. Here we investigate how hubs might contribute to robustness and other cellular properties for protein¡protein interactions dynamically regulated both in time and in space. We uncovered two types of hub: 'party' hubs, which interact with most of their partners simultaneously, and 'date' hubs, which bind their different partners at different times or locations. Both in silico studies of network connectivity and genetic interactions described in vivo support a model of organized modularity in which date hubs organize the proteome, connecting biological processesor modulesto each other, whereas party hubs function inside modules.