Details

Autor(en) / Beteiligte

• Shao, Yutian
• Molestak, Eliza
• Su, Weike
• Stankevič, Marek
• Tchórzewski, Marek

Titel

Sordarin— An anti‐fungal antibiotic with a unique modus operandi

Ist Teil von

• British journal of pharmacology, 2022-03, Vol.179 (6), p.1125-1145

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Fungal infections cause serious problems in many aspects of human life, in particular infections in immunocompromised patients present serious problems. Current anti‐fungal antibiotics target various metabolic pathways, predominantly the cell wall or cellular membrane metabolism. Numerous compounds are available to combat fungal infections, but their efficacy is far from satisfactory and some of them display high toxicity. The emerging antibiotic resistance represents a serious issue as well. Hence, there is a considerable need for new anti‐fungal compounds with lower toxicity and higher effectiveness. One of the unique anti‐fungal antibiotics is sordarin, the only known compound that acts on the fungal translational machinery per se. Sordarin inhibits protein synthesis at the elongation step of the translational cycle, acting on eukaryotic translation elongation factor 2. In this review, we deliver a robust scientific platform promoting the development of anti‐fungal compounds, in particular focusing on the molecular action of sordarin.