Details

Autor(en) / Beteiligte

• Pichla, Monika
• Sneyers, Flore
• Stopa, Kinga B.
• Bultynck, Geert
• Kerkhofs, Martijn

Titel

Dynamic control of mitochondria-associated membranes by kinases and phosphatases in health and disease

Ist Teil von

• Cellular and molecular life sciences : CMLS, 2021-10, Vol.78 (19-20), p.6541-6556

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Springer Nature - Complete Springer Journals

Beschreibungen/Notizen

• Membrane-contact sites are getting more and more credit for their indispensable role in maintenance of cell function and homeostasis. In the last decades, the ER–mitochondrial contact sites in particular received a lot of attention. While our knowledge of ER–mitochondrial contact sites increases steadily, the focus often lies on a static exploration of their functions. However, it is increasingly clear that these contact sites are very dynamic. In this review, we highlight the dynamic nature of ER–mitochondrial contact sites and the role of kinases and phosphatases therein with a focus on recent findings. Phosphorylation events allow for rapid integration of information on the protein level, impacting protein function, localization and interaction at ER–mitochondrial contact sites. To illustrate the importance of these events and to put them in a broader perspective, we connect them to pathologies like diabetes type II, Parkinson’s disease and cancer.