Details

Autor(en) / Beteiligte

• Qu, Ke-Jun
• Wang, Bin
• Jiang, Chang-Sheng
• Xie, Bao-Gang
• Liu, Ai-Hong
• Li, Song-Wei
• Guo, Yue-Wei
• Li, Jia
• Mao, Shui-Chun

Titel

Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra

Ist Teil von

• Journal of natural products (Washington, D.C.), 2021-08, Vol.84 (8), p.2303-2311

Ort / Verlag

United States

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Two novel rearranged Diels-Alder adducts, morunigrines A ( ) and B ( ), and four new prenylated flavonoids, morunigrols A-D ( - ), were isolated from the twigs of , together with four known prenylated phenolic compounds, including two flavonoids ( and ) and two 2-arylbenzofurans ( and ). Morunigrines A ( ) and B ( ) are a novel class of Diels-Alder adducts with unprecedented carbon skeletons featuring a rearranged chalcone-stilbene/2-arylbenzofuran core decorated with a unique methylbiphenyl moiety. The structures of the new compounds were assigned by analysis of spectroscopic data. The absolute configuration of compound was determined by the measurement of specific rotation. A plausible biogenetic pathway for and is also proposed. Compounds and exhibited more potent protein tyrosine phosphatase 1B inhibitory activity with IC values of 1.8 ± 0.2 and 1.3 ± 0.3 μM, respectively, than that of the positive control oleanolic acid (IC , 2.5 ± 0.1 μM).