Autor(en)
Yang, Xinrui; Pang, Yifan; Zhang, Jilei; Shi, Jinlong; Zhang, Xinpei; Zhang, Gaoqi; Yang, Siyuan; Wang, Jjng; Hu, Kai; Wang, Jijun; Jing, Hongmei; Ke, Xiaoyan; Fu, Lin
Titel
High Expression Levels of ACTN1 and ACTN3 Indicate Unfavorable Prognosis in Acute Myeloid Leukemia
Teil von
  • Journal of Cancer, 2019-01-01, Vol.10 (18), p.4286-4292
Ort / Verlag
LAKE HAVEN: IVYSPRING INT PUBL
Links zum Volltext
Quelle
Web of Science
Beschreibungen
Background: Actinins are major cytoskeletal proteins that mediate sarcomere function, and they also have important non-muscle functions such as regulating cytokinesis, cell adhesion and migration. There are four isoforms of actinins in mammals (ACTN1-4). Recently, the relationship between actinins and cancer has been discovered in many types of malignancy, yet their prognostic significance in acute myeloid leukemia (AML) remains unclear. Methods: We collected data of 155 de novo AML patients from The Cancer Genome Atlas (TCGA) database; 85 patients received chemotherapy only and 70 patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). We divided each treatment groups into sub-groups based on the median expression levels of ACTN1-4. Results: Survival analysis showed that in the chemotherapy-only group, high ACTN1 and ACTN3 expression were associated with shorter event-free survival (EFS) and overall survival (OS) (p<0.01). Multivariate analysis suggested that high expression of ACTN1 and ACTN3 (p<0.05) were independent poor prognostic factors. In the allo-HSCT group, ACTN1-4 expression had no impact on survival. Conclusions: Our study suggested that high expression levels of ACTN1 and ACTN3 adversely affected the survival of AML patients, but their harmful impact could be overcome by allo-HSCT.
Format
Sprache(n)
Englisch
Identifikator(en)
ISSN: 1837-9664
ISSN: 1837-9664
DOI: 10.7150/jca.31766
Links zum Inhalt
Schlagwörter
Life Sciences & Biomedicine, Oncology, Science & Technology
Systemstelle
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