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High Expression Levels of ACTN1 and ACTN3 Indicate Unfavorable Prognosis in Acute Myeloid Leukemia
Ist Teil von
Journal of Cancer, 2019-01, Vol.10 (18), p.4286-4292
Ort / Verlag
Australia: Ivyspring International Publisher Pty Ltd
Erscheinungsjahr
2019
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
: Actinins are major cytoskeletal proteins that mediate sarcomere function, and they also have important non-muscle functions such as regulating cytokinesis, cell adhesion and migration. There are four isoforms of actinins in mammals (ACTN1-4). Recently, the relationship between actinins and cancer has been discovered in many types of malignancy, yet their prognostic significance in acute myeloid leukemia (AML) remains unclear.
: We collected data of 155 de novo AML patients from The Cancer Genome Atlas (TCGA) database; 85 patients received chemotherapy only and 70 patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). We divided each treatment groups into sub-groups based on the median expression levels of
.
: Survival analysis showed that in the chemotherapy-only group, high
and
expression were associated with shorter event-free survival (EFS) and overall survival (OS) (p<0.01). Multivariate analysis suggested that high expression of
and
(p<0.05) were independent poor prognostic factors. In the allo-HSCT group,
expression had no impact on survival.
: Our study suggested that high expression levels of
and
adversely affected the survival of AML patients, but their harmful impact could be overcome by allo-HSCT.