Details

Autor(en) / Beteiligte

• Yang, Xinrui
• Pang, Yifan
• Zhang, Jilei
• Shi, Jinlong
• Zhang, Xinpei
• Zhang, Gaoqi
• Yang, Siyuan
• Wang, Jing
• Hu, Kai
• Wang, Jijun
• Jing, Hongmei
• Ke, Xiaoyan
• Fu, Lin

Titel

High Expression Levels of ACTN1 and ACTN3 Indicate Unfavorable Prognosis in Acute Myeloid Leukemia

Ist Teil von

• Journal of Cancer, 2019-01, Vol.10 (18), p.4286-4292

Ort / Verlag

Australia: Ivyspring International Publisher Pty Ltd

Erscheinungsjahr

2019

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• : Actinins are major cytoskeletal proteins that mediate sarcomere function, and they also have important non-muscle functions such as regulating cytokinesis, cell adhesion and migration. There are four isoforms of actinins in mammals (ACTN1-4). Recently, the relationship between actinins and cancer has been discovered in many types of malignancy, yet their prognostic significance in acute myeloid leukemia (AML) remains unclear. : We collected data of 155 de novo AML patients from The Cancer Genome Atlas (TCGA) database; 85 patients received chemotherapy only and 70 patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). We divided each treatment groups into sub-groups based on the median expression levels of . : Survival analysis showed that in the chemotherapy-only group, high and expression were associated with shorter event-free survival (EFS) and overall survival (OS) (p<0.01). Multivariate analysis suggested that high expression of and (p<0.05) were independent poor prognostic factors. In the allo-HSCT group, expression had no impact on survival. : Our study suggested that high expression levels of and adversely affected the survival of AML patients, but their harmful impact could be overcome by allo-HSCT.