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Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months
Ist Teil von
Journal of clinical periodontology, 2019-03, Vol.46 (3), p.321-331
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Aim
To assess the effect of periodontal therapy (PT) on cardiovascular blood biomarkers.
Materials and Methods
This single‐blind, parallel‐design, randomized controlled trial included patients with stable coronary artery disease and periodontitis. The test group (TG) received non‐surgical PT, whereas the control group (CG) received one session of plaque removal. Plasma levels of C‐reactive protein (CRP), glycated haemoglobin, lipids and cytokines (IL‐1β, IL‐6, IL‐8, IL‐10, IFN‐γ and TNF‐α) were measured at baseline and after 3 months.
Results
Eighty‐two patients (74.4% women, mean age 59.6 years) were analysed. TG had significantly better periodontal parameters than CG after 3 months, but no significant differences in blood markers were observed between them. In a post hoc subgroup analysis in patients with baseline CRP <3 mg/L, a significant increase in CRP was observed in CG (1.44 ± 0.82 mg/L to 4.35 ± 7.85 mg/L, p = 0.01), whereas CRP remained unchanged in TG (1.40 ± 0.96 mg/L to 1.33 ± 1.26 mg/L, p = 0.85), resulting in a significant difference between groups at 3 months. In patients with CRP ≥3 mg/L, a significant reduction in CRP was observed only in TG (11.3 ± 12.8 mg/L to 5.7 ± 4.1 mg/L, p = 0.04). Levels of IL‐6 and IL‐8 were significantly lower in TG than CG at 3 months.
Conclusions
PT leads to lower levels of CRP, IL‐6 and IL‐8 in cardiovascular patients with high CRP levels.