Details

Autor(en) / Beteiligte

• Mizuno, Shohei
• Kawamura, Koji
• Hanamura, Ichiro
• Sunami, Kazutaka
• Mori, Takehiko
• Nakamura, Fumihiko
• Iida, Shinsuke
• Nakazawa, Hideyuki
• Makita, Masanori
• Kako, Shinichi
• Sawa, Masashi
• Ueda, Yasunori
• Takahashi, Hiroyuki
• Kanda, Yoshinobu
• Ichinohe, Tatsuo
• Atsuta, Yoshiko
• Takamatsu, Hiroyuki
• Takami, Akiyoshi

Titel

Efficacy and safety of autologous stem cell transplantation in patients aged ≥ 65 years with multiple myeloma in the era of novel agents

Ist Teil von

• Bone marrow transplantation (Basingstoke), 2019-10, Vol.54 (10), p.1595-1604

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Clinical trials evaluating the role of autologous hematopoietic stem cell transplantation (auto-HCT) in multiple myeloma have mostly included patients aged <65 years. Therefore, this study was aimed to evaluate the efficacy and safety of auto-HCT in elderly patients with multiple myeloma in the era of novel agents. We retrospectively analyzed 2056 patients with multiple myeloma, who underwent auto-HCT in 2007-2014 (287 were aged ≥65 years). We evaluated the 100-day treatment-related mortality (TRM) and overall survival (OS) in two groups; elderly patients ( ≥65 years) who underwent auto-HCT compared with younger patients ( <65 years). In the propensity score-matched-pair analysis used to adjust for possible selection bias, the incidence of 100-day TRM between patients aged <65 (0.4%; 95% confidence interval [CI]: 0.0-2.0%) and ≥65 years (1.2%; 95% CI: 0.3-3.1%) showed no statistically significant difference (p = 0.31). The probability of the 5-year OS after transplantation in those aged <65 (62.5%; 95% CI: 58.6-66.1%) and ≥65 (63.5%; 95% CI: 52.2-72.7%) years was also not significantly different (p = 0.56). This study showed that the safety and efficacy of auto-HCT in elderly patients with multiple myeloma in the era of novel agents compared with younger patients were similar.