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Accessing Remote meta‐ and para‐C(sp2)−H Bonds with Covalently Attached Directing Groups
Ist Teil von
Angewandte Chemie (International ed.), 2019-08, Vol.58 (32), p.10820-10843
Auflage
International ed. in English
Ort / Verlag
Germany: Wiley Subscription Services, Inc
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Directing group assisted ortho‐C−H activation has been known for the last few decades. In contrast, extending the same approach to achieve activation of the distal meta‐ and para‐C−H bonds in aromatic molecules remained elusive for a long time. The main challenge is the conception of a macrocyclic transition state, which is needed to anchor the metal catalyst close to the target bond. Judicious modification of the chain length, the tether linkage, and the nature of the catalyst‐coordinating donor atom has led to a number of successful studies in the last few years. This Review compiles the significant achievements made in this field of both meta‐ and para‐selectivity using covalently attached directing groups, which are systematically classified on the basis of their mode of covalent attachment to the substrate as well as their chemical nature. This Review aims to create a more heuristic approach for recognizing the suitability of the directing groups for use in future organic transformations.
Hang‐ing there: Since its discovery in 2012, the use of directing groups for the meta/para‐C−H activation of aromatic molecules has come a long way. This Review gives an overview of covalently linked directing groups reported in the last few years.