Details

Autor(en) / Beteiligte

• Wang, Ya-Nan
• Xia, Gui-Yang
• Wang, Ling-Yan
• Ge, Guang-Bo
• Zhang, Hua-Wei
• Zhang, Jing-Fang
• Wu, Yu-Zhuo
• Lin, Sheng

Titel

Purpurolide A, 5/5/5 Spirocyclic Sesquiterpene Lactone in Nature from the Endophytic Fungus Penicillium purpurogenum

Ist Teil von

• Organic letters, 2018-11, Vol.20 (22), p.7341-7344

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpurolide A (1), an unprecedent sesquiterpene lactone with a rarely encountered 5/5/5 spirocyclic skeleton, along with two new 6/4/5/5 tetracyclic sesquiterpene lactones (2 and 3), were isolated from the cultures of the endophytic fungus Penicillium purpurogenum IMM003. The structures and absolute configurations of 1–3 were established by spectroscopic analysis, single-crystal X-ray diffraction, and calculations of the 13C NMR and ECD data. Compounds 1–3 showed significant inhibitory activity against pancreatic lipase.