UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Universitätsbibliothek
Katalog
Details
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Datensatz exportieren als...
BibTeX
Eph Receptor Effector Ephexin Mediates Olfactory Dendrite Targeting in Drosophila
Developmental neurobiology (Hoboken, N.J.), 2018-09, Vol.78 (9), p.873-888
Sardana, Juhi
Organisti, Cristina
Grunwald Kadow, Ilona C.
2018
Details
Autor(en) / Beteiligte
Sardana, Juhi
Organisti, Cristina
Grunwald Kadow, Ilona C.
Titel
Eph Receptor Effector Ephexin Mediates Olfactory Dendrite Targeting in Drosophila
Ist Teil von
Developmental neurobiology (Hoboken, N.J.), 2018-09, Vol.78 (9), p.873-888
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
ABSTRACT Deciphering the mechanisms of sensory neural map formation is a central aim in neurosciences. Failure to form a correct map frequently leads to defects in sensory processing and perception. The olfactory map develops in subsequent steps initially forming a rough and later a precise map of glomeruli in the antennal lobe (AL), mainly consisting of olfactory receptor neuron (ORN) axons and projection neuron (PN) dendrites. The mechanisms underpinning the later stage of class‐specific glomerulus formation are not understood. Recent studies have shown that the important guidance molecule Eph and its ligand ephrin play a role in class‐specific PN targeting. Here, we reveal aspects of the mechanism downstream of Eph signaling during olfactory map formation. We show that the Eph‐specific RhoGEF Ephexin (Exn) is required to fine tune PN dendrite patterning within specific glomeruli. We provide the first report showing an in vivo neurite guidance defect in an exn mutant. Interestingly, the quality of the phenotypes is different between eph and exn mutants; while loss of Eph leads to strong misprojections of DM3/Or47a neurons along the medial–lateral axis of the antennal lobe (AL), loss of Exn induces ventral ectopic innervation of a neighboring glomerulus. Genetic interaction experiments suggest that differential signaling of the small GTPases Rac1 and Cdc42 mediated by Exn‐dependent and ‐independent Eph signaling fine tunes spatial targeting of PN dendrites within the olfactory map. We propose that their distinct activities on the actin cytoskeleton are required for precise navigation of PN dendrites within the olfactory map. Taken together, our results suggest that the precise connectivity of an individual neuron can depend on different modes of signaling downstream of a single guidance receptor. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 00: 000–000, 2018
Sprache
Englisch
Identifikatoren
ISSN: 1932-8451
eISSN: 1932-846X
DOI: 10.1002/dneu.22624
Titel-ID: cdi_proquest_miscellaneous_2071577712
Format
–
Schlagworte
Actin
,
Animals
,
Antennal lobe
,
Axons
,
Axons - metabolism
,
Cdc42 protein
,
Cytoskeleton
,
Dendrites
,
Dendrites - physiology
,
Drosophila
,
Drosophila melanogaster - metabolism
,
Drosophila Proteins - metabolism
,
Eph
,
Ephexin
,
ephrin
,
Fruit flies
,
Glomerulus
,
Information processing
,
Innervation
,
Membrane Proteins - metabolism
,
Mutants
,
Neural networks
,
Neurogenesis - physiology
,
Olfactory glomeruli
,
olfactory map formation
,
Olfactory Pathways - metabolism
,
Olfactory Receptor Neurons - metabolism
,
Phenotypes
,
projection neurons
,
Rac1 protein
,
Rho GTPases
,
Sensory integration
,
Spatial discrimination
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX