Details

Autor(en) / Beteiligte

• Jiao, Zhiwei
• Lim, Li Hui
• Hirao, Hajime
• Zhou, Jianrong Steve

Titel

Palladium‐Catalyzed para‐Selective Alkylation of Electron‐Deficient Arenes

Ist Teil von

• Angewandte Chemie (International ed.), 2018-05, Vol.57 (21), p.6294-6298

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Intermolecular alkylations of electron‐deficient arenes proceed with good para selectivity. Palladium catalysts were used to generate nucleophilic alkyl radicals from alkyl halides, which then directly add onto the arenes. The arene scope and the site of alkylation are opposite to those of classical Friedel–Crafts alkylations, which prefer electron‐rich systems. Anti‐Friedel–Crafts alkylation: Intermolecular radical alkylations of electron‐deficient arenes by palladium radical catalysis proceed with para selectivity. The types of arenes and the site of addition on the arenes are opposite to those of classical Friedel–Crafts alkylation reactions.