Details

Autor(en) / Beteiligte

• Ioannidis, John P A
• Bhattacharya, Siladitya
• Evers, J L H
• der Veen, Fulco van
• Somigliana, Edgardo
• Barratt, Christopher L R
• Bontempi, Gianluca
• Baird, David T
• Crosignani, PierGiorgio
• Devroey, Paul
• Diedrich, Klaus
• Farquharson, Roy G
• Fraser, Lynn R
• Geraedts, Joep P M
• Gianaroli, Luca
• La Vecchia, Carlo
• Magli, Cristina
• Negri, Eva
• Sunde, Arne
• Tapanainen, Juha S
• Tarlatzis, Basil C
• Steirteghem, Andre Van
• Veiga, Anna

Titel

Protect us from poor-quality medical research

Ist Teil von

• Human reproduction (Oxford), 2018-05, Vol.33 (5), p.770-776

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.