Details

Autor(en) / Beteiligte

• Jeong, Hyun Jeong
• Lee, Hyun Ju
• Ko, Jung Hwa
• Cho, Bum-Joo
• Park, Se Yeon
• Park, Jong Woo
• Choi, Se Rang
• Heo, Jang Won
• Yoon, Sun-Ok
• Oh, Joo Youn

Titel

Myeloid-Derived Suppressor Cells Mediate Inflammation Resolution in Humans and Mice with Autoimmune Uveoretinitis

Ist Teil von

• The Journal of immunology (1950), 2018-02, Vol.200 (4), p.1306-1315

Ort / Verlag

United States: American Association of Immunologists

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Resolution of inflammation is an active process that leads to tissue homeostasis and involves multiple cellular and molecular mechanisms. Myeloid-derived suppressor cells (MDSCs) have recently emerged as important cellular components in the resolution of inflammation because of their activities to suppress T cell activation. In this article, we show that HLA-DR CD11b CD33 CD14 human MDSCs and CD11b Ly6G Ly6C mouse MDSCs markedly increased in patients and mice during and before the resolution phase of autoimmune uveoretinitis. CD11b Ly6C monocytes isolated from autoimmune uveoretinitis mice were able to suppress T cell proliferation in culture, and adoptive transfer of the cells accelerated the remission of autoimmune uveoretinitis in mice. Alternatively, depletion of CD11b Ly6C monocytes at the resolution phase, but not CD11b Ly6G granulocytes, exacerbated the disease. These findings collectively indicate that monocytic MDSCs serve as regulatory cells mediating the resolution of autoimmune uveoretinitis.