Details

Autor(en) / Beteiligte

• Zi Xu, Yang Xin
• Ande, Sudharsana Rao
• Mishra, Suresh

Titel

Prohibitin: A new player in immunometabolism and in linking obesity and inflammation with cancer

Ist Teil von

• Cancer letters, 2018-02, Vol.415, p.208-216

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2018

Quelle

Elsevier ScienceDirect

Beschreibungen/Notizen

• Immunometabolism, which has important implications in cancer biology, has emerged as a major regulator of different immune cell types. Various factors that integrate metabolic switches within immune cells with signal directed program that promote or inhibit their functions remain largely unidentified. Furthermore, sex differences are known to exist in immune functions and cancer incidences in the body and sex steroid hormones are integral component of these differences. However, factors that mediate such differences, and the potential link between the two fundamental aspects of immune cell biology that contributes to sex differences in health and disease remain unexplored. New evidence derived from novel tissue-specific transgenic mouse models of prohibitin (PHB) has revealed its crucial role in sex differences in adipocyte and macrophage functions and a potential role in endocrine-immune crosstalk. This review provides a point of view on the emerging role of PHB in immune functions with special focus on immunometabolism and on the immunomodulatory effects of sex steroids. We propose that PHB plays a crucial role in integrating cell signaling events with metabolic switches, and may serve as a potential target for cancer immunotherapeutic. •PHB plays a crucial role in sex differences in adipose and immune functions.•PHB and sex steroids regulate each other's functions in adipocyte and immune cells.•PHB has a role in the immunomodulatory effects of estrogen.•PHB integrates cell signaling events with immunometabolism.