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Breast Cancer—Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual
CA: a cancer journal for clinicians, 2017-07, Vol.67 (4), p.290-303
Giuliano, Armando E.
Connolly, James L.
Edge, Stephen B.
Mittendorf, Elizabeth A.
Rugo, Hope S.
Solin, Lawrence J.
Weaver, Donald L.
Winchester, David J.
Hortobagyi, Gabriel N.
2017
Details
Autor(en) / Beteiligte
Giuliano, Armando E.
Connolly, James L.
Edge, Stephen B.
Mittendorf, Elizabeth A.
Rugo, Hope S.
Solin, Lawrence J.
Weaver, Donald L.
Winchester, David J.
Hortobagyi, Gabriel N.
Titel
Breast Cancer—Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual
Ist Teil von
CA: a cancer journal for clinicians, 2017-07, Vol.67 (4), p.290-303
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Answer questions and earn CME/CNE The revision of the eighth edition of the primary tumor, lymph node, and metastasis (TNM) classification of the American Joint Commission of Cancer (AJCC) for breast cancer was determined by a multidisciplinary team of breast cancer experts. The panel recognized the need to incorporate biologic factors, such as tumor grade, proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression prognostic panels into the staging system. AJCC levels of evidence and guidelines for all tumor types were followed as much as possible. The panel felt that, to maintain worldwide value, the tumor staging system should remain based on TNM anatomic factors. However, the recognition of the prognostic influence of grade, hormone receptor expression, and HER2 amplification mandated their inclusion into the staging system. The value of commercially available, gene‐based assays was acknowledged and prognostic input added. Tumor biomarkers and low Oncotype DX recurrence scores can alter prognosis and stage. These updates are expected to provide additional precision and flexibility to the staging system and were based on the extent of published information and analysis of large, as yet unpublished databases. The eighth edition of the AJCC TNM staging system, thus, provides a flexible platform for prognostic classification based on traditional anatomic factors, which can be modified and enhanced using patient biomarkers and multifactorial prognostic panel data. The eighth edition remains the worldwide basis for breast cancer staging and will incorporate future online updates to remain timely and relevant. CA Cancer J Clin 2017;67:290–303. © 2017 American Cancer Society.
Sprache
Englisch
Identifikatoren
ISSN: 0007-9235
eISSN: 1542-4863
DOI: 10.3322/caac.21393
Titel-ID: cdi_proquest_miscellaneous_1877852576
Format
–
Schlagworte
Biomarkers
,
Biomarkers, Tumor
,
Breast cancer
,
Breast Neoplasms - classification
,
Breast Neoplasms - pathology
,
Classification
,
distant metastases
,
ductal carcinoma in situ
,
Epidermal growth factor
,
ErbB-2 protein
,
estrogen receptor
,
Estrogens
,
Female
,
Gene expression
,
human epidermal growth receptor 1 (HER2)
,
Humans
,
infiltrating ductal carcinoma
,
infiltrating lobular carcinoma
,
lobular carcinoma in situ
,
Lymph
,
lymph node metastases
,
Lymph nodes
,
Lymphatic Metastasis
,
Metastases
,
Metastasis
,
neoadjuvant chemotherapy
,
Neoplasm Metastasis
,
Neoplasm Staging - methods
,
Practice Guidelines as Topic
,
Progesterone
,
Prognosis
,
United States
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