Genome Biology, 2016-10, Vol.17 (1), p.204-204, Article 204
2016
Details
- Autor(en) / Beteiligte
- Titel
- Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis
- Ist Teil von
- Genome Biology, 2016-10, Vol.17 (1), p.204-204, Article 204
- Ort / Verlag
- England: BioMed Central
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- SpringerNature Journals
- Beschreibungen/Notizen
- It has proven exceedingly difficult to ascertain rare copy number alterations (CNAs) that may have strong effects in individual tumors. We show that a regulatory network inferred from gene expression and gene copy number data of 768 human cancer cell lines can be used to quantify the impact of patient-specific CNAs on survival signature genes. A focused analysis of tumors from six tissues reveals that rare patient-specific gene CNAs often have stronger effects on signature genes than frequent gene CNAs. Further comparison to a related network-based approach shows that the integration of indirectly acting gene CNAs significantly improves the survival analysis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1474-760X, 1474-7596eISSN: 1474-760XDOI: 10.1186/s13059-016-1058-1Titel-ID: cdi_proquest_miscellaneous_1835390194
- Format
- –
- Schlagworte
- Cancer, Computational Biology, Copy number, DNA Copy Number Variations - genetics, Gene expression, Gene Expression Regulation, Neoplastic, Generalized linear models, Genomes, Genomics, Humans, Method, Mutation, Neoplasms - genetics, Neoplasms - pathology, Oligonucleotide Array Sequence Analysis, Organ Specificity - genetics, Survival analysis, Systems Biology, Tissue Distribution, Tumor cell lines, Tumorigenesis, Tumors