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Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation
Cancer letters, 2016-07, Vol.377 (2), p.149-157
2016

Details

Autor(en) / Beteiligte
Titel
Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation
Ist Teil von
  • Cancer letters, 2016-07, Vol.377 (2), p.149-157
Ort / Verlag
Ireland: Elsevier Ireland Ltd
Erscheinungsjahr
2016
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
  • Highlights • BaF3/ITD-R and MV4-11-R are resistant to type I and type II TKIs. • TKI resistant leukemia cells show significant mitochondrial dysfunction. • TKI resistant leukemia cells show upregulation of glycolytic activity. • TKI resistant leukemia cells are highly sensitive to glycolytic inhibitors.
Sprache
Englisch
Identifikatoren
ISSN: 0304-3835
eISSN: 1872-7980
DOI: 10.1016/j.canlet.2016.04.040
Titel-ID: cdi_proquest_miscellaneous_1805501301
Format
–
Schlagworte
Angiogenesis Inhibitors - pharmacology, Animals, Apoptosis, Apoptosis - drug effects, Cell Line, Tumor, Cell Proliferation - drug effects, Deoxyglucose - pharmacology, Dose-Response Relationship, Drug, Drug Resistance, Neoplasm - drug effects, Drug Resistance, Neoplasm - genetics, FLT3/ITD, fms-Like Tyrosine Kinase 3 - antagonists & inhibitors, fms-Like Tyrosine Kinase 3 - genetics, fms-Like Tyrosine Kinase 3 - metabolism, G2 Phase Cell Cycle Checkpoints - drug effects, Genes, Genetic Predisposition to Disease, Glycolysis, Glycolysis - drug effects, Hematology, Oncology and Palliative Medicine, Humans, Kinases, Leukemia, Myeloid, Acute - drug therapy, Leukemia, Myeloid, Acute - enzymology, Leukemia, Myeloid, Acute - genetics, Leukemia, Myeloid, Acute - pathology, Metabolic alterations, Mice, Mitochondria, Mitochondria - drug effects, Mitochondria - metabolism, Mutation, Niacinamide - analogs & derivatives, Niacinamide - pharmacology, Phenotype, Phenylurea Compounds - pharmacology, Protein Kinase Inhibitors - pharmacology, Pyruvates - pharmacology, Signal Transduction - drug effects, Tandem Repeat Sequences, Time Factors, TKI resistance

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