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Purpose
Polymer-xerogel composite materials have been introduced to better optimize local anesthetics release kinetics for the pain management. In a previous study, it was shown that by adjusting various compositional and nano-structural properties of both inorganic xerogels and polymers, zero-order release kinetics over 7 days can be achieved
in vitro
. In this study,
in vitro
release properties are confirmed
in vivo
using a model that tests for actual functionality of the released local anesthetics.
Methods
Composite materials made with tyrosine-polyethylene glycol(PEG)-derived poly(ether carbonate) copolymers and silica-based sol–gel (xerogel) were synthesized. The
in vivo
release from the composite controlled release materials was demonstrated by local anesthetics delivery in a rat incisional pain model.
Results
The tactile allodynia resulting from incision was significantly attenuated in rats receiving drug-containing composites compared with the control and sham groups for the duration during which natural healing had not yet taken place. The concentration of drug (bupivacaine) in blood is dose dependent and maintained stable up to 120 h post-surgery, the longest time point measured.
Conclusions
These
in vivo
studies show that polymer-xerogel composite materials with controlled release properties represent a promising class of controlled release materials for pain management.