UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Universitätsbibliothek
Katalog
Details
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Datensatz exportieren als...
BibTeX
Structural basis of the Inv compartment and ciliary abnormalities in Inv/nphp2 mutant mice
Cytoskeleton (Hoboken, N.J.), 2016-01, Vol.73 (1), p.45-56
Tsuji, Takuma
Matsuo, Kazuhiko
Nakahari, Takashi
Marunaka, Yoshinori
Yokoyama, Takahiko
2016
Details
Autor(en) / Beteiligte
Tsuji, Takuma
Matsuo, Kazuhiko
Nakahari, Takashi
Marunaka, Yoshinori
Yokoyama, Takahiko
Titel
Structural basis of the Inv compartment and ciliary abnormalities in Inv/nphp2 mutant mice
Ist Teil von
Cytoskeleton (Hoboken, N.J.), 2016-01, Vol.73 (1), p.45-56
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
The primary cilium is a hair like structure protruding from most mammalian cells. The basic design of the primary cilium consists of a nine microtubule doublet structure (the axoneme). The Inv compartment, a distinct proximal segment of the ciliary body, is defined as the region in which the Inv protein is localized. Inv gene is a responsible gene for human nephronophthisis type2 (NPHP2). Here, we show that renal cilia have a short proximal microtubule doublet region and a long distal microtubule singlet region. The length of the Inv compartment was similar to that of the microtubule doublet region, suggesting a possibility that the doublet region is the structural basis of the Inv compartment. Respiratory cilia of inv mouse mutants had ciliary rootlet malformation and showed reduced ciliary beating frequency and ciliary beating angle, which may explain recurrent bronchitis in NPHP2 patients. In multiciliated tracheal cells, most Inv proteins were retained in the basal body and did not accumulate in the Inv compartment. These results suggest that the machinery to transport and retain Inv in cilia is different between renal and tracheal cilia and that Inv may function in the basal body of tracheal cells. © 2015 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1949-3584
eISSN: 1949-3592
DOI: 10.1002/cm.21264
Titel-ID: cdi_proquest_miscellaneous_1761471849
Format
–
Schlagworte
Animals
,
axoneme
,
Cell Movement
,
Cilia - metabolism
,
Cilia - pathology
,
Humans
,
Inv
,
Inv compartment
,
Kidney - metabolism
,
Kidney - pathology
,
Mice
,
Mice, Knockout
,
Microscopy, Electron
,
Microscopy, Fluorescence
,
Microtubules - metabolism
,
Mutation - genetics
,
NPHP2
,
primary cilia
,
Subcellular Fractions
,
Trachea - metabolism
,
Trachea - pathology
,
Transcription Factors - physiology
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX