Details

Autor(en) / Beteiligte

• van der Paardt, Anne-Fleur
• Wilffert, Bob
• Akkerman, Onno W
• de Lange, Wiel C M
• van Soolingen, Dick
• Sinha, Bhanu
• van der Werf, Tjip S
• Kosterink, Jos G W
• Alffenaar, Jan-Willem C

Titel

Evaluation of macrolides for possible use against multidrug-resistant Mycobacterium tuberculosis

Ist Teil von

• The European respiratory journal, 2015-08, Vol.46 (2), p.444-455

Ort / Verlag

England

Erscheinungsjahr

2015

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Multidrug-resistant tuberculosis (MDR-TB) is a major global health problem. The loss of susceptibility to an increasing number of drugs behoves us to consider the evaluation of non-traditional anti-tuberculosis drugs.Clarithromycin, a macrolide antibiotic, is defined as a group 5 anti-tuberculosis drug by the World Health Organization; however, its role or efficacy in the treatment of MDR-TB is unclear. A systematic review of the literature was conducted to summarise the evidence for the activity of macrolides against MDR-TB, by evaluating in vitro, in vivo and clinical studies. PubMed and Embase were searched for English language articles up to May 2014.Even though high minimum inhibitory concentration values are usually found, suggesting low activity against Mycobacterium tuberculosis, the potential benefits of macrolides are their accumulation in the relevant compartments and cells in the lungs, their immunomodulatory effects and their synergistic activity with other anti-TB drugs.A future perspective may be use of more potent macrolide analogues to enhance the activity of the treatment regimen.