Details

Autor(en) / Beteiligte

• Getahun, Haileyesus
• Matteelli, Alberto
• Chaisson, Richard E
• Raviglione, Mario
• Campion, Edward W
• Campion, Edward W.

Titel

Latent Mycobacterium tuberculosis Infection

Ist Teil von

• The New England journal of medicine, 2015-05, Vol.372 (22), p.2127-2135

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• About one third of the world population has latent M. tuberculosis infection. This review explains the approach to patients with latent infection, including an update on the risks and benefits of treatment and assessment of the likelihood of progression to active disease. The natural history of tuberculosis begins with the inhalation of Mycobacterium tuberculosis organisms; a period of bacterial replication and dissemination ensues, followed by immunologic containment of viable bacilli. The result of this process is asymptomatic latent tuberculosis infection, which is defined as a state of persistent bacterial viability, immune control, and no evidence of clinically manifested active tuberculosis. 1 Currently, it is not possible to directly diagnose M. tuberculosis infection in humans; therefore, latent tuberculosis infection is diagnosed by response to in vivo or in vitro stimulation by M. tuberculosis antigens with the use of the tuberculin skin test or interferon-γ . . .