Details

Autor(en) / Beteiligte

• Schumacher, Ton N.
• Schreiber, Robert D.

Titel

Neoantigens in cancer immunotherapy

Ist Teil von

• Science (American Association for the Advancement of Science), 2015-04, Vol.348 (6230), p.69-74

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2015

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• The clinical relevance of T cells in the control of a diverse set of human cancers is now beyond doubt. However, the nature of the antigens that allow the immune system to distinguish cancer cells from noncancer cells has long remained obscure. Recent technological innovations have made it possible to dissect the immune response to patient-specific neoantigens that arise as a consequence of tumor-specific mutations, and emorging data suggest that recognition of such neoantigens is a major factor in the activity of clinical immunotherapies. These observations indicate that neoantigen load may form a biomarker in cancer immunotherapy and provide an incentive for the development of novel therapeutic approaches that selectively enhance T cell reactivity against this class of antigens.