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Angewandte Chemie (International ed.), 2015-01, Vol.54 (4), p.1098-1129
Auflage
International ed. in English
Ort / Verlag
Weinheim: WILEY-VCH Verlag
Erscheinungsjahr
2015
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
The base sequence of nucleic acid encodes structural and functional properties into the biopolymer. Structural information includes the formation of duplexes, G‐quadruplexes, i‐motif, and cooperatively stabilized assemblies. Functional information encoded in the base sequence involves the strand‐displacement process, the recognition properties by aptamers, and the catalytic functions of DNAzymes. This Review addresses the implementation of the information encoded in nucleic acids to develop DNA switches. A DNA switch is a supramolecular nucleic acid assembly that undergoes cyclic, switchable, transitions between two distinct states in the presence of appropriate triggers and counter triggers, such as pH value, metal ions/ligands, photonic and electrical stimuli. Applications of switchable DNA systems to tailor switchable DNA hydrogels, for the controlled drug‐release and for the activation of switchable enzyme cascades, are described, and future perspectives of the systems are addressed.
Switched on: The stimuli‐triggered reversible reconfiguration of i‐motifs, G‐quadruplexes, and duplex DNA structures, and of DNA devices, such as tweezers, nanosprings or walkers, are the basis for DNA switches that can be triggered by changes in pH values, metal ions/ligands, and photonic or electrochemical signals. Applications of DNA switches include controlled drug delivery, opening/closure of pores, and switchable catalysis.