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Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus
Journal of bone and mineral research, 2015-01, Vol.30 (1), p.3-23
Khan, Aliya A
Morrison, Archie
Hanley, David A
Felsenberg, Dieter
McCauley, Laurie K
O'Ryan, Felice
Reid, Ian R
Ruggiero, Salvatore L
Taguchi, Akira
Tetradis, Sotirios
Watts, Nelson B
Brandi, Maria Luisa
Peters, Edmund
Guise, Teresa
Eastell, Richard
Cheung, Angela M
Morin, Suzanne N
Masri, Basel
Cooper, Cyrus
Morgan, Sarah L
Obermayer‐Pietsch, Barbara
Langdahl, Bente L
Al Dabagh, Rana
Davison, K. Shawn
Kendler, David L
Sándor, George K
Josse, Robert G
Bhandari, Mohit
El Rabbany, Mohamed
Pierroz, Dominique D
Sulimani, Riad
Saunders, Deborah P
Brown, Jacques P
Compston, Juliet
2015
Details
Autor(en) / Beteiligte
Khan, Aliya A
Morrison, Archie
Hanley, David A
Felsenberg, Dieter
McCauley, Laurie K
O'Ryan, Felice
Reid, Ian R
Ruggiero, Salvatore L
Taguchi, Akira
Tetradis, Sotirios
Watts, Nelson B
Brandi, Maria Luisa
Peters, Edmund
Guise, Teresa
Eastell, Richard
Cheung, Angela M
Morin, Suzanne N
Masri, Basel
Cooper, Cyrus
Morgan, Sarah L
Obermayer‐Pietsch, Barbara
Langdahl, Bente L
Al Dabagh, Rana
Davison, K. Shawn
Kendler, David L
Sándor, George K
Josse, Robert G
Bhandari, Mohit
El Rabbany, Mohamed
Pierroz, Dominique D
Sulimani, Riad
Saunders, Deborah P
Brown, Jacques P
Compston, Juliet
Titel
Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus
Ist Teil von
Journal of bone and mineral research, 2015-01, Vol.30 (1), p.3-23
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2015
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
This work provides a systematic review of the literature from January 2003 to April 2014 pertaining to the incidence, pathophysiology, diagnosis, and treatment of osteonecrosis of the jaw (ONJ), and offers recommendations for its management based on multidisciplinary international consensus. ONJ is associated with oncology‐dose parenteral antiresorptive therapy of bisphosphonates (BP) and denosumab (Dmab). The incidence of ONJ is greatest in the oncology patient population (1% to 15%), where high doses of these medications are used at frequent intervals. In the osteoporosis patient population, the incidence of ONJ is estimated at 0.001% to 0.01%, marginally higher than the incidence in the general population (<0.001%). New insights into the pathophysiology of ONJ include antiresorptive effects of BPs and Dmab, effects of BPs on gamma delta T‐cells and on monocyte and macrophage function, as well as the role of local bacterial infection, inflammation, and necrosis. Advances in imaging include the use of cone beam computerized tomography assessing cortical and cancellous architecture with lower radiation exposure, magnetic resonance imaging, bone scanning, and positron emission tomography, although plain films often suffice. Other risk factors for ONJ include glucocorticoid use, maxillary or mandibular bone surgery, poor oral hygiene, chronic inflammation, diabetes mellitus, ill‐fitting dentures, as well as other drugs, including antiangiogenic agents. Prevention strategies for ONJ include elimination or stabilization of oral disease prior to initiation of antiresorptive agents, as well as maintenance of good oral hygiene. In those patients at high risk for the development of ONJ, including cancer patients receiving high‐dose BP or Dmab therapy, consideration should be given to withholding antiresorptive therapy following extensive oral surgery until the surgical site heals with mature mucosal coverage. Management of ONJ is based on the stage of the disease, size of the lesions, and the presence of contributing drug therapy and comorbidity. Conservative therapy includes topical antibiotic oral rinses and systemic antibiotic therapy. Localized surgical debridement is indicated in advanced nonresponsive disease and has been successful. Early data have suggested enhanced osseous wound healing with teriparatide in those without contraindications for its use. Experimental therapy includes bone marrow stem cell intralesional transplantation, low‐level laser therapy, local platelet‐derived growth factor application, hyperbaric oxygen, and tissue grafting. © 2014 American Society for Bone and Mineral Research © 2014 American Society for Bone and Mineral Research
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.2405
Titel-ID: cdi_proquest_journals_1640522116
Format
–
Schlagworte
Antibodies, Monoclonal, Humanized - adverse effects
,
Antibodies, Monoclonal, Humanized - therapeutic use
,
Bacterial Infections - immunology
,
Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnosis
,
Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnostic imaging
,
Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology
,
Bisphosphonate-Associated Osteonecrosis of the Jaw - immunology
,
Bisphosphonate-Associated Osteonecrosis of the Jaw - therapy
,
BISPHOSPHONATES
,
Cone-Beam Computed Tomography
,
Consensus
,
DENOSUMAB
,
DIAGNOSIS
,
Diphosphonates - adverse effects
,
Diphosphonates - therapeutic use
,
Humans
,
IMAGING
,
Macrophages - immunology
,
Macrophages - pathology
,
MANAGEMENT
,
Mandible - diagnostic imaging
,
Mandible - immunology
,
Monocytes - immunology
,
Monocytes - pathology
,
OSTEONECROSIS OF THE JAW
,
Osteoporosis - diagnosis
,
Osteoporosis - diagnostic imaging
,
Osteoporosis - drug therapy
,
Osteoporosis - immunology
,
Receptors, Antigen, T-Cell, gamma-delta - immunology
,
RISK FACTORS
,
T-Lymphocytes - immunology
,
T-Lymphocytes - pathology
,
TREATMENT
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