Details

Autor(en) / Beteiligte

• Valkovič, Ladislav
• Bogner, Wolfgang
• Gajdošík, Martin
• Považan, Michal
• Kukurová, Ivica Just
• Krššák, Martin
• Gruber, Stephan
• Frollo, Ivan
• Trattnig, Siegfried
• Chmelík, Marek

Titel

One-dimensional image-selected in vivo spectroscopy localized phosphorus saturation transfer at 7T

Ist Teil von

• Magnetic resonance in medicine, 2014-12, Vol.72 (6), p.1509-1515

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose To evaluate the feasibility of a one‐dimensional image‐selected in vivo spectroscopy (1D‐ISIS) saturation transfer (ST) sequence at 7T for localized in vivo measurements of energy metabolism in different tissues in clinically reasonable examination times. Methods The performance of a gradient offset independent adiabacity‐based 1D‐ISIS localization was tested on phantom and the localized ST sequence was compared with the nonlocalized version in vivo. We performed localized measurements of basal metabolism of human liver and different muscle groups of the calf. Localized ST experiments took 15–25 minutes. Results The selectivity of the 1D‐ISIS sequence was 81.63% and the outer volume suppression was 97.57%. The ST parameters acquired with the 1D‐ISIS sequence and with the nonlocalized acquisition in the muscle were not statistically different. The forward rate constants for phosphocreatine (PCr)–adenosine triphosphate (ATP) and inorganic phosphate (Pi)–ATP exchange reactions were measured in the soleus (kCK = 0.30 ± 0.06 s−1 and kATP = 0.11 ± 0.02 s−1, respectively) and in the medial gastrocnemius (kCK = 0.27 ± 0.06 s−1 and kATP = 0.09 ± 0.03s−1, respectively) in 15 minutes per muscle group. The corresponding fluxes were FCK = 6.26 ± 1.28 μmol/g/s, FATP = 0.22 ± 0.05 μmol/g/s and FCK = 6.29 ± 1.66 μmol/g/s, FATP = 0.21 ± 0.07 μmol/g/s, for soleus and gastrocnemius, respectively. The hepatic ATP synthesis measurement was feasible in 24 minutes. Conclusion The fast assessment of PCr–ATP and Pi–ATP exchange rates at 7T makes the 1D‐ISIS ST sequence a promising tool for examining local resting‐state metabolism in clinically acceptable measurement times. Magn Reson Med 72:1509–1515, 2014. © 2014 Wiley Periodicals, Inc.