Details

Autor(en) / Beteiligte

• Leung, Cecilia S
• Yeung, Tsz-Lun
• Yip, Kay-Pong
• Pradeep, Sunila
• Balasubramanian, Lavanya
• Liu, Jinsong
• Wong, Kwong-Kwok
• Mangala, Lingegowda S
• Armaiz-Pena, Guillermo N
• Lopez-Berestein, Gabriel
• Sood, Anil K
• Birrer, Michael J
• Mok, Samuel C

Titel

Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential

Ist Teil von

• Nature communications, 2014-10, Vol.5 (1), p.5092-5092, Article 5092

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Ovarian cancer is the most lethal gynaecologic malignancy in the United States, and advanced serous ovarian adenocarcinoma is responsible for most ovarian cancer deaths. However, the stroma-derived molecular determinants that modulate patient survival are yet to be characterized. Here we identify a stromal gene signature for advanced high-grade serous ovarian cancer using microdissected stromal ovarian tumour samples and find that stromal microfibrillar-associated protein 5 (MFAP5) is a prognostic marker for poor survival. Further functional studies reveal that FAK/CREB/TNNC1 signalling pathways mediate the effect of MFAP5 on ovarian cancer cell motility and invasion potential. Targeting stromal MFAP5 using MFAP5-specific siRNA encapsulated in chitosan nanoparticles significantly decreases ovarian tumour growth and metastasis in vivo, suggesting that it may be a new modality of ovarian cancer treatment.