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Elevated norharman plasma levels in alcoholic patients and controls resulting from tobacco smoking
Ist Teil von
Life sciences (1973), 1996, Vol.58 (17), p.1425-1432
Ort / Verlag
Netherlands: Elsevier Inc
Erscheinungsjahr
1996
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Plasma norharman and harman levels were measured by solvent extraction and HPLC with fluorescence detection in alcohol-dependent patients undergoing in-patient abstinence treatment and in control subjects. In both groups, randomly collected samples from smokers contained higher mean norharman levels than those from non-smokers. In three volunteers norharman concentrations rose sharply after smoking of one or two cigarettes and declined to near-basal levels within one hour after one cigarette. When 12 patients kept a smoking-free interval of at least 6 h, they had similarly low plasma norharman concentrations (20 ± 8 pg/ml) as 18 non-smoking control subjects (17 ± 8 pg/ml) or as 13 smoking controls who had abstained from smoking (20 ± 6 pg/ml). Ten of the patients smoked one cigarette and within 5–10 min attained norharman levels of 177 ± 147 pg/ml plasma. The high prevalence of smokers among chronic alcoholics probably explains the previous finding of elevated norharman plasma levels in these patients.