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In vitro biological and mechanical evaluation of various scaffold materials for myocardial tissue engineering
Journal of biomedical materials research. Part A, 2014-04, Vol.102 (4), p.958-966
Herrmann, Florian E. M.
Lehner, Anja
Hollweck, Trixi
Haas, Ulrike
Fano, Cornelia
Fehrenbach, David
Kozlik-Feldmann, Rainer
Wintermantel, Erich
Eissner, Gunther
Hagl, Christian
Akra, Bassil
2014
Details
Autor(en) / Beteiligte
Herrmann, Florian E. M.
Lehner, Anja
Hollweck, Trixi
Haas, Ulrike
Fano, Cornelia
Fehrenbach, David
Kozlik-Feldmann, Rainer
Wintermantel, Erich
Eissner, Gunther
Hagl, Christian
Akra, Bassil
Titel
In vitro biological and mechanical evaluation of various scaffold materials for myocardial tissue engineering
Ist Teil von
Journal of biomedical materials research. Part A, 2014-04, Vol.102 (4), p.958-966
Ort / Verlag
Hoboken, NJ: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
A cardiac patch is a construct devised in regenerative medicine to replace necrotic heart tissue after myocardial infarctions. The cardiac patch consists of a scaffold seeded with stem cells. To identify the best scaffold for cardiac patch construction we compared polyurethane, Collagen Cell Carriers, ePTFE, and ePTFE SSP1‐RGD regarding their receptiveness to seeding with mesenchymal stem cells isolated from umbilical cord tissue. Seeding was tested at an array of cell seeding densities. The bioartificial patches were cultured for up to 35 days and evaluated by scanning electron microscopy, microscopy of histological stains, fluorescence microscopy, and mitochondrial assays. Polyurethane was the only biomaterial which resulted in an organized multilayer (seeding density: 0.750 × 106 cells/cm2). Cultured over 35 days at this seeding density the mitochondrial activity of the cells on polyurethane patches continually increased. There was no decrease in the E Modulus of polyurethane once seeded with cells. Seeding of CCC could only be realized at a low seeding density and both ePTFE and ePTFE SSP1‐RGD were found to be unreceptive to seeding. Of the tested scaffolds polyurethane thus crystallized as the most appropriate for seeding with mesenchymal stem cells in the framework of myocardial tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 958–966, 2014.
Sprache
Englisch
Identifikatoren
ISSN: 1549-3296
eISSN: 1552-4965
DOI: 10.1002/jbm.a.34786
Titel-ID: cdi_proquest_miscellaneous_1504457117
Format
–
Schlagworte
Biological and medical sciences
,
biomaterials
,
Biomechanical Phenomena - drug effects
,
Biomedical materials
,
Biotechnology
,
cell transplantation
,
Collagen - pharmacology
,
Construction
,
Density
,
Elastic Modulus - drug effects
,
Fundamental and applied biological sciences. Psychology
,
Health. Pharmaceutical industry
,
heart disease
,
Humans
,
Industrial applications and implications. Economical aspects
,
Materials Testing
,
Medical sciences
,
Mesenchymal Stromal Cells - cytology
,
Mesenchymal Stromal Cells - drug effects
,
Mesenchymal Stromal Cells - metabolism
,
Microscopy
,
Microscopy, Electron, Scanning
,
Miscellaneous
,
Mitochondria - drug effects
,
Mitochondria - metabolism
,
Myocardium - metabolism
,
Nucleation
,
Polytetrafluoroethylene - pharmacology
,
Polyurethane resins
,
Polyurethanes - pharmacology
,
Propidium - metabolism
,
Scaffolds
,
Staining and Labeling
,
Stem cells
,
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
,
Surgical implants
,
Technology. Biomaterials. Equipments
,
tissue engineering
,
Tissue Engineering - methods
,
Tissue Scaffolds - chemistry
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