UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Universitätsbibliothek
Katalog
Details
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Datensatz exportieren als...
BibTeX
Increased vulnerability of the spinal cord to radiation or intrathecal chemotherapy during adolescence: A report from the Children's Oncology Group
Pediatric blood & cancer, 2009-12, Vol.53 (7), p.1205-1210
Bleyer, Archie
Choi, Mehee
Wang, Samuel J.
Fuller, Clifton D.
Raney, R. Beverly
2009
Details
Autor(en) / Beteiligte
Bleyer, Archie
Choi, Mehee
Wang, Samuel J.
Fuller, Clifton D.
Raney, R. Beverly
Titel
Increased vulnerability of the spinal cord to radiation or intrathecal chemotherapy during adolescence: A report from the Children's Oncology Group
Ist Teil von
Pediatric blood & cancer, 2009-12, Vol.53 (7), p.1205-1210
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Purpose To assess the rate of spinal cord toxicity in adolescents resulting from chemoradiotherapy of parameningeal sarcoma. Methods and Materials Of 152 patients with parameningeal sarcoma treated per the Intergroup Rhabdomyosarcoma Study Group protocol from 1977 through 1989, eight developed paralyzing ascending myelitis after intrathecal chemotherapy with cytosine arabinoside, methotrexate, and hydrocortisone administered during and after radiation therapy to volumes that included part of the spinal cord. The eight cases include three not previously published. Results Of eight patients who developed CNS toxicity after intrathecal chemotherapy and radiotherapy for parameningeal rhabdomyosarcoma, all but one were between 13 and 18 years of age when treated. This severe toxicity occurred in one quarter of 28 adolescents treated with the regimen in comparison with one of 123 children 12 years of age or less (P < 0.0001), a rate that was as much as 30 times higher in the adolescents. Lengthening of the spinal cord during the pubertal growth spurt may account for the apparent increased vulnerability. Conclusions Chemoradiotoxicity‐associated spinal cord injury appears to be more likely to occur in adolescents than in younger or older ages. This observation appears to reverse a conventional wisdom in which the central nervous system is thought to become more resistant to the neurotoxic effects of chemoradiotherapy as it matures. Pediatr Blood Cancer 2009; 53:1205–1210. © 2009 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1545-5009, 1545-5017
eISSN: 1545-5017
DOI: 10.1002/pbc.22164
Titel-ID: cdi_proquest_miscellaneous_1367482421
Format
–
Schlagworte
adolescence
,
Adolescent - physiology
,
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
,
Antineoplastic Combined Chemotherapy Protocols - adverse effects
,
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
,
Child
,
Cranial Irradiation - adverse effects
,
Cyclophosphamide - administration & dosage
,
Cytarabine - administration & dosage
,
Cytarabine - adverse effects
,
Dacarbazine - administration & dosage
,
Dactinomycin - administration & dosage
,
Etoposide - administration & dosage
,
Female
,
Humans
,
Hydrocortisone - administration & dosage
,
Hydrocortisone - adverse effects
,
Injections, Spinal
,
intrathecal chemotherapy
,
Male
,
Meninges - pathology
,
Methotrexate - administration & dosage
,
Methotrexate - adverse effects
,
Myelitis - chemically induced
,
Myelitis - etiology
,
Myelitis - physiopathology
,
Neoplasm Invasiveness
,
Puberty
,
Radiation Injuries - etiology
,
Radiation Injuries - physiopathology
,
radiation myelopathy
,
Retrospective Studies
,
Rhabdomyosarcoma - drug therapy
,
Rhabdomyosarcoma - pathology
,
Rhabdomyosarcoma - radiotherapy
,
sarcoma
,
Sarcoma, Ewing - drug therapy
,
Sarcoma, Ewing - radiotherapy
,
spinal cord
,
Spinal Cord - drug effects
,
Spinal Cord - growth & development
,
Spinal Cord - radiation effects
,
Spinal Neoplasms - drug therapy
,
Spinal Neoplasms - pathology
,
Spinal Neoplasms - radiotherapy
,
Vincristine - administration & dosage
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX