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Falsely elevated testosterone in a type 1 diabetes patients with acne and chronic renal failure on dialysis
Ist Teil von
Arquivos brasileiros de endocrinologia e metabologia, 2012-07, Vol.56 (5), p.319-323
Ort / Verlag
Brazil
Erscheinungsjahr
2012
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
The purpose of this report is to present the case of a patient with type 1 diabetes with acne and chronic renal failure on dialysis admitted to the hospital with high total total and free testosterone (612 ng/dL, normal < 90 ng/dL; 255 pMol/L, normal: 20-45 pMol/L). On clinical evaluation, she presented facial acne, and no other signs of hyperandrogenism. As this result was confirmed, she underwent adrenal and ovary morphological assessment (adrenal CT and pelvic ultrasound), which yielded normal results. Due to divergence between clinical and laboratory findings, we considered other possibilities that could explain the elevation of testosterone, including the presence of comorbidities (diabetes and chronic renal failure) and failure of the testosterone assay. Testosterone levels were determined again by high performance liquid chromatography, as a preparative method, and tandem mass spectrometry, yielding normal results (21 ng/dL), which were compatible with a falsely elevated total testosterone level caused by the presence of factors that intereferred with the assay.