Details
- Autor(en) / Beteiligte
- Titel
- Systems and synthetic biology of the vessel wall
- Ist Teil von
- FEBS letters, 2012-07, Vol.586 (15), p.2164-2170
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- Wiley Online Library
- Beschreibungen/Notizen
- Atherosclerosis is intimately coupled to blood flow by the presence of predilection sites. The coupling is through mechanotransduction of endothelial cells and approximately 2000 gene are associated with this process. This paper describes a new platform to study and identify new signalling pathways in endothelial cells covering an atherosclerotic plaque. The identified networks are synthesized in primary cells to study their reaction to flow. This synthetic approach might lead to new insights and drug targets.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/j.febslet.2012.04.031Titel-ID: cdi_proquest_miscellaneous_1024350553
- Format
- –
- Schlagworte
- ACS, acute coronary syndromes, Atherosclerosis - genetics, Atherosclerosis - metabolism, Atherosclerosis - pathology, Atherosclerosis - physiopathology, Blood Circulation - genetics, Blood Vessels - cytology, Blood Vessels - metabolism, Blood Vessels - physiology, Blood Vessels - physiopathology, cell specific SAM, coefficient of variation, Computer Simulation, csSAM, CV, Endothelial Cells - metabolism, gene set enrichment analysis, Genomics, GGM, graphical, GSEA, Imaging, Three-Dimensional, Kruppel-Like Transcription Factors - metabolism, Mechanotransduction, NF-kappa B - metabolism, PCA, principal component analysis, RMA, robust multi-array averaging, SAM, Signal Transduction - genetics, significance analysis of microarrays, Synthetic biology, Synthetic Biology - methods, Systems Biology - methods, Systems medicine, TCFA, thin cap fibroatheroma, Transcriptome, Vascular