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Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes
The New England journal of medicine, 2020-11, Vol.383 (21), p.2007-2017
2020

Details

Autor(en) / Beteiligte
Titel
Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes
Ist Teil von
  • The New England journal of medicine, 2020-11, Vol.383 (21), p.2007-2017
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2020
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
  • In this phase 2 trial, children and young adults with newly diagnosed overt type 1 diabetes were randomly assigned to receive golimumab, a human monoclonal antibody to tumor necrosis factor α , or placebo. Golimumab resulted in better endogenous insulin production and less exogenous insulin use than placebo.
Sprache
Englisch
Identifikatoren
ISSN: 0028-4793
eISSN: 1533-4406
DOI: 10.1056/NEJMoa2006136
Titel-ID: cdi_proquest_journals_2462160755
Format
–
Schlagworte
Adolescent, Age, Antibodies, Monoclonal - adverse effects, Antibodies, Monoclonal - pharmacology, Antibodies, Monoclonal - therapeutic use, Antigens, Area Under Curve, Arthritis, Autoimmune diseases, Beta cells, C-Peptide - metabolism, Child, Children, Diabetes, Diabetes mellitus (insulin dependent), Diabetes Mellitus, Type 1 - blood, Diabetes Mellitus, Type 1 - drug therapy, Diabetes Mellitus, Type 1 - metabolism, Disease, Double-Blind Method, Drug Therapy, Combination, Female, Glucose, Glycated Hemoglobin A - analysis, Hemoglobin, Humans, Hypoglycemia, Hypoglycemia - chemically induced, Hypoglycemic Agents - administration & dosage, Hypoglycemic Agents - adverse effects, Immunological tolerance, Insulin, Insulin - administration & dosage, Insulin - adverse effects, Insulin - metabolism, Insulin-Secreting Cells - drug effects, Insulin-Secreting Cells - metabolism, Laboratories, Male, Metabolism, Monoclonal antibodies, Pancreas, Peptides, Proinsulin - metabolism, R&D, Remission, Research & development, TNF inhibitors, Tumor Necrosis Factor-alpha - antagonists & inhibitors, Tumor necrosis factor-TNF, Tumor necrosis factor-α, Young Adult, Young adults

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