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This paper presents two new interaction integrals for calculating stress-intensity factors (SIFs) for a stationary crack in two-dimensional orthotropic functionally graded materials of arbitrary geometry. The method involves the finite element discretization, where the material properties are smooth functions of spatial co-ordinates and two newly developed interaction integrals for mixed-mode fracture analysis. These integrals can also be implemented in conjunction with other numerical methods, such as meshless method, boundary element method, and others. Three numerical examples including both mode-I and mixed-mode problems are presented to evaluate the accuracy of SIFs calculated by the proposed interaction integrals. Comparisons have been made between the SIFs predicted by the proposed interaction integrals and available reference solutions in the literature, generated either analytically or by finite element method using various other fracture integrals or analyses. An excellent agreement is obtained between the results of the proposed interaction integrals and the reference solutions.