Details

Autor(en) / Beteiligte

• Anzueto, Antonio
• Baughman, Robert P
• Guntupalli, Kalpalatha K
• Weg, John G
• Wiedemann, Herbert P
• Raventós, Antoni Artigas
• Lemaire, François
• Long, Walker
• Zaccardelli, David S
• Pattishall, Edward N

Titel

Aerosolized Surfactant in Adults with Sepsis-Induced Acute Respiratory Distress Syndrome

Ist Teil von

• The New England journal of medicine, 1996-05, Vol.334 (22), p.1417-1422

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1996

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• When Ashbaugh et al. 1 described the acute respiratory distress syndrome (ARDS) in 1967, they suggested that the clinical and pathological findings in patients with this condition were in part due to abnormalities in the alveolar wall. Petty et al. 2 , 3 later reported both qualitative and quantitative abnormalities in lung surfactant in patients with ARDS. Hallman et al. 4 confirmed that surfactant not only is decreased in quantity but also is functionally abnormal in patients with ARDS. These studies offer evidence that ARDS is a condition of surfactant deficiency. 5 Recent data suggest that mechanical ventilation may induce lung damage. Dreyfuss et al. . . .