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Reduced Skeletal Muscle Oxygen Uptake and Reduced [beta]-Cell Function Two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes
Thamer et al present a study testing the hypothesis that family history of type 2 diabetes mellitus (T2DM) is associated with reduced maximal oxidative capacity independent of alterations in insulin sensitivity. The data gathered were compatible with the hypothesis that familial predisposition for T2DM impairs maximal oxygen consumption in skeletal muscle, and because habitual physical activity was not different, genetic factors may be involved. Conceivably, reduced maximal oxidative capacity precedes skeletal muscle insulin resistance, providing a partial explanation for discrepancies in the literature.