Details

Autor(en) / Beteiligte

• TSCHRITTER, Otto
• FRITSCHE, Andreas
• THAMER, Claus
• HAAP, Michael
• SHIRKAVAND, Fatemeh
• RAHE, Stefanie
• STAIGER, Harald
• MAERKER, Elke
• HÄRING, Hans
• STUMVOLL, Michael

Titel

Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism

Ist Teil von

• Diabetes (New York, N.Y.), 2003-02, Vol.52 (2), p.239-243

Ort / Verlag

Alexandria, VA: American Diabetes Association

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism Otto Tschritter , Andreas Fritsche , Claus Thamer , Michael Haap , Fatemeh Shirkavand , Stefanie Rahe , Harald Staiger , Elke Maerker , Hans Häring and Michael Stumvoll From the Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard-Karls-Universität, Tübingen, Germany Abstract In animals, the adipocyte-derived hormone adiponectin has been shown to improve insulin sensitivity, a key factor in the pathogenesis of type 2 diabetes. In Pima Indians, high plasma adiponectin levels are associated with increased insulin sensitivity and reduced risk of type 2 diabetes. It is unclear whether this is also the case in white individuals and whether an additional beneficial effect on lipid metabolism exists. We therefore analyzed in nondiabetic individuals the associations between plasma adiponectin concentrations and insulin sensitivity measured by a euglycemic-hyperinsulinemic clamp ( n = 262) and estimated by an oral glucose tolerance test (OGTT; n = 636) and serum lipid parameters using correlational analysis. Plasma adiponectin concentrations were positively correlated with insulin sensitivity, both measured with the clamp ( r = 0.28, P = 0.0015 in women; r = 0.42, P < 0.0001 in men) and estimated from the OGTT ( r = 0.37, P < 0.0001 in women; r = 0.41, P < 0.0001 in men) before and after adjusting for sex and percentage of body fat (all P < 0.001). Fasting triglycerides and the free fatty acid (FFA) concentrations during the OGTT (area under the curve) and at 120 min were negatively correlated in both women and men, whereas HDL was positively correlated with plasma adiponectin concentrations (all P < 0.004). Most notable, these relationships remained significant after adjusting for insulin sensitivity of glucose disposal in addition to sex and percentage of body fat (all P < 0.05). In conclusion, high adiponectin predicts increased insulin sensitivity. This relationship is independent of low body fat mass and affects not only insulin-stimulated glucose disposal but also lipoprotein metabolism and insulin-mediated suppression of postprandial FFA release. This suggests pleiotropic insulin sensitizing effects of adiponectin in humans. Footnotes Address correspondence and reprint requests to Dr. Michael Stumvoll, Medizinische Universitätsklinik, Otfried-Müller-Strasse 10, D-72076 Tübingen, Germany. E-mail: michael.stumvoll{at}med.uni-tuebingen.de . Received for publication 19 September 2002 and accepted in revised form 28 October 2002. AUC, area under the curve; FFA, free fatty acid; IGT, impaired glucose tolerance; ISI, insulin sensitivity index; NGT, normal glucose tolerance; OGTT, oral glucose tolerance test; PPAR-γ, peroxisome proliferator-activated receptor-γ; RQ, respiratory quotient; WHR, waist-to-hip ratio. DIABETES