Details

Autor(en) / Beteiligte

• Heemskerk, A. Dorothee
• Bang, Nguyen D
• Mai, Nguyen T.H
• Chau, Tran T.H
• Phu, Nguyen H
• Loc, Pham P
• Chau, Nguyen V.V
• Hien, Tran T
• Dung, Nguyen H
• Lan, Nguyen T.N
• Lan, Nguyen H
• Lan, Nguyen N
• Phong, Le T
• Vien, Nguyen N
• Hien, Nguyen Q
• Yen, Nguyen T.B
• Ha, Dang T.M
• Day, Jeremy N
• Caws, Maxine
• Merson, Laura
• Thinh, Tran T.V
• Wolbers, Marcel
• Thwaites, Guy E
• Farrar, Jeremy J

Titel

Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis

Ist Teil von

• The New England journal of medicine, 2016-01, Vol.374 (2), p.124-134

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Tuberculous meningitis remains highly lethal. In this trial, an intensified regimen of levofloxacin and higher-dose rifampin added to standard therapy was compared with standard antituberculosis therapy alone. The intensified regimen did not result in a higher survival rate. Early treatment with antituberculosis chemotherapy and adjunctive treatment with glucocorticoids reduce the rate of death and disability from tuberculous meningitis, but the disease still kills or disables almost half the patients with the condition. 1 , 2 The current guidelines recommend treatment with four antituberculosis drugs for at least the first 2 months of therapy, followed by treatment with two drugs (rifampin and isoniazid) for an additional 7 to 10 months. 3 , 4 However, these recommendations are based on data from pulmonary tuberculosis and do not take into account the differential ability of antituberculosis drugs to penetrate the brain. Rifampin is considered to . . .