Details

Autor(en) / Beteiligte

• Xu, Jinzhong
• Hasegawa, Masateru
• Harada, Ken-ichi
• Kobayashi, Hisayoshi
• Nagai, Hiroshi
• Namikoshi, Michio

Titel

Melophlins P, Q, R, and S

Ist Teil von

• Chemical & pharmaceutical bulletin, 2006-06, Vol.54 (6), p.852

Ort / Verlag

Tokyo: Japan Science and Technology Agency

Erscheinungsjahr

2006

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Four new tetramic acid derivatives, named melophlins P, Q, R, and S (1--4), were isolated from two marine sponges of the genus Melophlus collected at Palau, together with seven known melophlins A, D, E, G, H, I, and O. The structures of the new compounds were elucidated on the basis of their spectral data. The absolute stereochemistries at the tetramic acid moieties of the new compounds were determined as 1 : 1 mixtures (racemic) by ESI-LC/MS analysis of derivatives obtained by oxidation and hydrolysis of the respective parent compounds. Melophlins P--S (1--4) showed cytotoxicity against the murine leukemia cell line L1210 with IC50 values of 20.0, 10.5, 0.85, and 5.13 μM, respectively.