Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...

Details

Autor(en) / Beteiligte
Titel
Assessment of Striatal Dopamine D2/D3 Receptor Availability with PET and ^sup 18^F-Desmethoxyfallypride: Comparison of Imaging Protocols Suited for Clinical Routine
Ist Teil von
  • The Journal of nuclear medicine (1978), 2012-10, Vol.53 (10), p.1558
Ort / Verlag
New York: Society of Nuclear Medicine
Erscheinungsjahr
2012
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
  • Assessment of striatal dopamine receptor availability with ^sup 18^F-desmethoxyfallypride PET is of high diagnostic utility in parkinsonism. The present study was undertaken to define the optimal clinical scan protocol with regard to quantification accuracy and scan time. Methods: Fourteen patients with parkinsonian syndromes underwent ^sup 18^F-desmethoxyfallypride PET over 90 min. Volume-of-interest analyses were performed after spatial normalization, with the right and leftcaudate nuclei and putamina as target regions and the cerebellum as reference region. The estimate of target region binding potential (relative to nondisplaceable radioligand in tissue) (BP^sub ND^) provided by the 2-step simplified reference tissue model (SRTM2) served as the reference standard. Additional analyses included the multilinear reference tissue model 2 (MRTM2), noninvasive graphical analyses, and single-scan analyses (peak-equilibrium analysis at 35-65 min [PEA]; pseudoequilibrium analysis at 60-90 min [PsEA]). Results: SRTM2 and MRTM2 yielded virtually identical results (mean BP^sub ND^ difference 5 0.1% ± 0.5%, r^sup 2^ = 1.0). Noninvasive graphical analyses with and without inclusion of the k^sub 2^' term were affected by a small BP^sub ND^ bias (2.5% 6 3.6% and 25.0% ± 6.7%, respectively), although correlations with SRTM2 were still excellent (r^sup 2^ = 1.0 and 0.98, respectively). In turn, singlescan analyses suffered from limited precision (PEA, mean BP^sub ND^ bias 5 0.7% ± 13.0%, r^sup 2^ = 0.90) or a considerable positive bias (PsEA, 19.2% ± 7.1%, r^sup 2^ - 0.98). Shortening scan time to 70 and 60 min resulted in an acceptable average BP^sub ND^ change (<5% decline) for SRTM2/MRTM2 and graphical analysis with inclusion of the k^sub 2^' term, respectively. Conclusion: Kinetic reference tissue model analyses of ^sup 18^F-desmethoxyfallypride PET data offer the least biased results at a well-tolerable scan duration and should thus be pursued whenever possible. Single-scan analyses may be pragmatic alternatives that, however, suffer from a relevant positive bias (PsEA) or limited precision (PEA). [PUBLICATION ABSTRACT]
Sprache
Englisch
Identifikatoren
ISSN: 0161-5505
eISSN: 1535-5667
Titel-ID: cdi_proquest_journals_1114146605

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX