Details

Autor(en) / Beteiligte

• Wu, Hon-Yen
• Hung, Kuan-Yu
• Huang, Tao-Min
• Hu, Fu-Chang
• Peng, Yu-Sen
• Huang, Jenq-Wen
• Lin, Shuei-Liong
• Chen, Yung-Ming
• Chu, Tzong-Shinn
• Tsai, Tun-Jun
• Wu, Kwan-Dun
• Fiorina, Paolo

Titel

Safety issues of long-term glucose load in patients on peritoneal dialysis--a 7-year cohort study

Ist Teil von

• PloS one, 2012-01, Vol.7 (1), p.e30337

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2012

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Effects of long-term glucose load on peritoneal dialysis (PD) patient safety and outcomes have seldom been reported. This study demonstrates the influence of long-term glucose load on patient and technique survival. We surveyed 173 incident PD patients. Long-term glucose load was evaluated by calculating the average dialysate glucose concentration since initiation of PD. Risk factors were assessed by fitting Cox's models with repeatedly measured time-dependent covariates. We noted that older age, higher glucose concentration, and lower residual renal function (RRF) were significantly associated with a worse patient survival. We found that female gender, absence of diabetes, lower glucose concentration, use of icodextrin, higher serum high density lipoprotein cholesterol, and higher RRF were significantly associated with a better technique survival. Long-term glucose load predicted mortality and technique failure in chronic PD patients. These findings emphasize the importance of minimizing glucose load in PD patients.