PloS one, 2008-02, Vol.3 (2), p.e1589
2008
Details
- Autor(en) / Beteiligte
- Titel
- Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure
- Ist Teil von
- PloS one, 2008-02, Vol.3 (2), p.e1589
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striatum with and without subsequent acute and chronic L-dopa treatment using two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry. The present data suggest that the dopamine-depleted striatum is so sensitive to de novo L-dopa treatment that the first ever administration alone would be able (i) to induce rapid post-translational modification-based proteomic changes that are specific to this first exposure and (ii), possibly, lead to irreversible protein level changes that would be not further modified by chronic L-dopa treatment. The apparent equivalence between first and chronic L-dopa administration suggests that priming would be the direct consequence of dopamine loss, the first L-dopa administrations only exacerbating the sensitization process but not inducing it.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0001589Titel-ID: cdi_plos_journals_1312185098
- Format
- –
- Schlagworte
- Analysis, Animals, Bayesian analysis, Bioinformatics, Chromatography, Chronic exposure, Corpus Striatum - chemistry, Dihydroxyphenylalanine, Disease Models, Animal, Dopa, Dopamine, Dyskinesia, Dyskinesia, Drug-Induced - metabolism, Electrophoresis, Gel, Two-Dimensional, Experiments, Exposure, FARMACI, Fourier transforms, Gel electrophoresis, Gene expression, Immunoglobulins, Levodopa, Levodopa - administration & dosage, Levodopa - adverse effects, Macaca, Mass Spectrometry, Mass spectroscopy, Movement disorders, MPTP, NATURAL SCIENCES, NATURVETENSKAP, Neostriatum, Neurodegenerative diseases, Neuroscience/Neurobiology of Disease and Regeneration, Neurosciences, Parkinson Disease - complications, Parkinson Disease - drug therapy, Parkinson's disease, Parkinsons disease, Peptides, Pharmaceuticals, PHARMACY, Phenols, Post-translation, Post-translational modification, Priming, Protein Processing, Post-Translational, Proteins, Proteomics - methods, Rats, Resveratrol, Rodents, Scientific imaging, Time series