A new pulse sequence element, spin-state-selective excitation (S3E), is introduced and combined with E.COSY-type techniques for measurement of 1H-1H J coupling constants. S3E edits the two resonances of a doublet prior to an evolution period of a multidimensional experiment and results in a subspectrum for each resonance. Due to this editing the large heteronuclear one-bond coupling constants normally exploited for separation of submultiplets in E.COSY-type experiments can be suppressed in experiments employing S3E. Hence there is a concomitant effective increase in resolution. Apart from pulse imperfections and relaxation during a delay (4J)-1 S3E causes no loss of sensitivity in comparison to conventional experiments. Experimental confirmation is done using the protein RAP 17-97 (N-terminal domain of alpha2-macroglobulin receptor associated protein).