Mechanisms of development, 2017-02, Vol.143, p.9-19
2017
Details
- Autor(en) / Beteiligte
- Titel
- Mechanisms of retinoic acid signaling during cardiogenesis
- Ist Teil von
- Mechanisms of development, 2017-02, Vol.143, p.9-19
- Ort / Verlag
- Ireland: Elsevier B.V
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Substantial experimental and epidemiological data have highlighted the interplay between nutritional and genetic factors in the development of congenital heart defects. Retinoic acid (RA), a derivative of vitamin A, plays a key role during vertebrate development including the formation of the heart. Retinoids bind to RA and retinoid X receptors (RARs and RXRs) which then regulate tissue-specific genes. Here, we will focus on the roles of RA signaling and receptors in gene regulation during cardiogenesis, and the consequence of deregulated retinoid signaling on heart formation and congenital heart defects. •We review the role of retinoic acid, a derivative of vitamin A, during heart development.•We review transcriptional activities of retinoic acid and retinoid X receptors in mammalian heart development.•We discuss the role of retinoids in congenital heart defects.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0925-4773eISSN: 1872-6356DOI: 10.1016/j.mod.2016.12.002Titel-ID: cdi_hal_primary_oai_HAL_inserm_01430833v1
- Format
- –
- Schlagworte
- Aldehyde Oxidoreductases - genetics, Aldehyde Oxidoreductases - metabolism, Animals, Cell fate decisions, Development Biology, Drosophila melanogaster - embryology, Drosophila melanogaster - genetics, Drosophila melanogaster - metabolism, Gene Expression Regulation, Developmental, Heart - embryology, Heart development, Homeodomain Proteins - genetics, Homeodomain Proteins - metabolism, Humans, Life Sciences, LIM-Homeodomain Proteins - genetics, LIM-Homeodomain Proteins - metabolism, Mice, Organogenesis - genetics, Retinoic acid, Retinoic acid receptors, Retinoid X Receptors - genetics, Retinoid X Receptors - metabolism, Signal Transduction, Transcription Factors - genetics, Transcription Factors - metabolism, Tretinoin - metabolism, Zebrafish - embryology, Zebrafish - genetics, Zebrafish - metabolism