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Cascade Reactions in Multicompartmentalized Polymersomes
Ist Teil von
Angewandte Chemie (International ed.), 2014-01, Vol.53 (1), p.146-150
Auflage
International ed. in English
Ort / Verlag
Weinheim: WILEY-VCH Verlag
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Enzyme‐filled polystyrene‐b‐poly(3‐(isocyano‐L‐alanyl‐aminoethyl)thiophene) (PS‐b‐PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene‐b‐poly(ethylene oxide) (PB‐b‐PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor‐dependent three‐enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments.
Mimicking cells: Enzyme‐filled polystyrene‐b‐poly(3‐(isocyano‐L‐alanylaminoethyl)thiophene) (PS‐b‐PIAT) nanoreactors have been encapsulated together with free enzymes and substrates in a larger polymersome to form a multicompartmentalized structure, which shows structural resemblance to a cell and its organelles (see picture). An original cofactor‐dependent three‐enzyme cascade reaction, with either compatible or incompatible enzymes, takes place across multiple compartments.