Autor(en)
Golubic, Sanja Josef
Titel
TRIPLE MODEL OF AUDITORY SENSORY PROCESSING: A NOVEL GATING STREAM DIRECTLY LINKS PRIMARY AUDITORY AREAS TO EXECUTIVE PREFRONTAL CORTEX/TRI PUTA OBRADE SLUSNIH PODRAZAJA: NOVI 'GATING PUT' IZRAVNO POVEZUJE PRIMARNA OSJETNA PODRUCJA S IZVRSNIM PREFRONTALNIM KORTEKSOM
Teil von
  • Acta clinica Croatica (Tisak), 2020-12-01, Vol.59 (4), p.721
Ort / Verlag
Klinicki bolnicki centar Sestre milosrdnice
Links zum Volltext
Quelle
Free Medical Journals
Beschreibungen
The generally accepted model of sensory processing of visual and auditory stimuli assumes two major parallel processing streams, ventral and dorsal, which comprise functionally and anatomically distinct but interacting processes in which the ventral stream supports stimulus identification, and the dorsal stream is involved in recognizing the stimulus spatial location and sensori-motor integration functions. However, recent studies suggest the existence of a third, very fast sensory processing pathway, a gating stream that directly links the primary auditory cortices to the executive prefrontal cortex within the first 50 milliseconds after presentation of a stimulus, bypassing hierarchical structure of the ventral and dorsal pathways. Gating stream propagates the sensory gating phenomenon, which serves as a basic protective mechanism preventing irrelevant, repeated information from recurrent sensory processing. The goal of the present paper is to introduce the novel 'three-stream' model of auditory processing, including the new fast sensory processing stream, i.e. gating stream, alongside the well-affirmed dorsal and ventral sensory processing pathways. The impairments in sensory processing along the gating stream have been found to be strongly involved in the pathophysiological sensory processing in Alzheimer's disease and could be the underlying issue in numerous neuropsychiatric disorders and diseases that are linked to the pathological sensory gating inhibition, such as schizophrenia, post-traumatic stress disorder, bipolar disorder or attention deficit hyperactivity disorder. Key words: Sensory processing; Dorsal stream; Ventral stream; Gating stream; Dual model of sensory processing; Triple model of sensory processing; Alzheimer's disease; Schizophrenia; Post-traumatic stress disorder; Attention-deficit/hyperactivity disorder Trenutno prihvaceni model obrade vidnih i slusnih podrazaja unutar velikog mozga pretpostavlja dva velika usporedna osjetna puta, ventralni i dorzalni, koji obuhvacaju funkcionalno i anatomski razlicite, ali ne i medusobno iskljucive mehanizme kojima se obraduju pojedina svojstva osjetne informacije. Ventralni put ima kljucnu ulogu u identifikaciji sadrzaja informacije, dok je dorzalni prvenstveno ukljucen u prostornu lokalizaciju izvora podrazaja i percepciju kretanja. Medutim, nova neurofizioloska istrazivanja ukazuju na postojanje treceg, vrlo brzog puta procesiranja podrazaja, "gating puta" koji izravno povezuje primarna osjetna podrucja s prefrontalnim dijelovima mozdane kore vec unutar prvih 50 milisekunda od izlaganja podrazaju, na taj nacin zaobilazeci hijearhijski ustroj dorzalnog i ventralnog puta. Gating put omogucava brzo generiranje osjetnog gating efekta koji sluzi kao temeljni, pred-perceptivni zastitni mehanizam s ulogom sprjecavanja opetovane obrade ponovljene i/ili nevazne osjetne informacije. Namjera ovoga preglednog rada je predstavljanje novog "trostrukog modela" paralelnih putova obrade osjetnih informacija uvodenjem treceg, vrlo brzog puta, gating puta, uz dva klinicki vec siroko prihvacena, ventralni i dorzalni. O klinickoj vaznosti novoga gating puta svjedoce najnoviji rezultati koji pokazuju da su poremecaji u gating procesiranju duz novoga osjetnog puta kljucni u otkrivanju Alzheimerove bolesti, s potencijalom da otkriju neurofizioloske znakove bolesti i u predklinickoj fazi. Patoloske promjene u osjetnom procesiranju duz novootkrivenoga gating puta mogli bi biti uzroci niza neuropsiholoskih i neuroloskih bolesti i stanja koja su vezana uz promjene u inhibiciji neuralnog odgovora na ponovljeni podrazaj (gating poremecaj), poput shizofrenije, poslijetraumatskog stresnog poremecaja ili poremecaja hiperaktivnosti i deficita paznje. Kljucne rijeci: Osjetno procesiranje; Osjetni gating put; Ventralni put; Dorzalni put; Trostruki model osjetnog procesiranja; Alzheimerova bolest; Shizofrenija; Poslijetraumatski stresni poremecaj; Poremecaj hiperaktivnosti i deficita paznje
Format
Sprache(n)
Englisch
Identifikator(en)
ISSN: 0353-9466
ISSN: 1333-9451
DOI: 10.20471/acc.2020.59.04.19

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