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EFFECT OF METHIMAZOLE THERAPY ON THYROID PATHOHISTOLOGY THAT MAY MIMIC THYROID MALIGNANCY/UCINAK TERAPIJE METIMAZOLOM NA PATOHISTOLOSKI IZGLED TKIVA STITNJACE KOJI MOZE OPONASATI MALIGNE PROMJENE.(Case Report)
Diffuse toxic goiter, as the most common cause of hyperthyroidism, is usually initially treated with thyrostatic drugs such as methimazole, followed by radioiodine therapy or surgery which may be indicated as definitive treatment. Radioactive iodine therapy has a known association with various histopathologic features including cytologic atypia, but herein we present a rare example of morphological thyrocyte changes induced by long-term pharmacological treatment with methimazole that mimicked thyroid malignancy in a pathohistological sample. Key words: hyperthyroidism, thyrostatic drugs, thyroid neoplasms Difuzna toksicna struma, kao najucestaliji uzrok hipertireoze, se uglavnom lijeci tireostaticima kao sto je metimazol a nakon pocetne farmakoloske terapije, ukoliko ne dode do spontane remisije bolesti, lijecenje se nastavlja primjenom radioaktivnog joda (1-131) ili kirurskim zahvatom. Primjena radioaktivnog joda dovodi do brojnih histopatoloskih izmjena u parenhimu stitnjace, ukljucujuci i stanicnu atipiju, no u nasem radu prikazujemo rijedak slucaj utjecaja dugotrajne farmakoloske terapije metimazolom na izmjenu morfologije tireocita koja moze oponasati izgled malignih stanica na histoloskom uzorku tkiva stitnjace. Kljucne rijeci: hipertireoza, tireostatska terapija, neoplazme stitnjace