Details

Autor(en) / Beteiligte

• GRAY, Juliette
• YEO, Giles S. H
• HODGES, John R
• RAYMOND, F. Lucy
• O'RAHILLY, Stephen
• SADAF FAROOQI, I
• COX, James J
• MORTON, Jenny
• ADLAM, Anna-Lynne R
• KEOGH, Julia M
• YANOVSKI, Jack A
• EL GHARBAWY, Areeg
• HAN, Joan C
• LORAINE TUNG, Y. C

Titel

Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene

Ist Teil von

• Diabetes (New York, N.Y.), 2006-12, Vol.55 (12), p.3366-3371

Ort / Verlag

Alexandria, VA: American Diabetes Association

Erscheinungsjahr

2006

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor ( BDNF ) Gene Juliette Gray 1 , Giles S.H. Yeo 1 , James J. Cox 2 , Jenny Morton 3 , Anna-Lynne R. Adlam 4 , Julia M. Keogh 1 , Jack A. Yanovski 5 , Areeg El Gharbawy 5 , Joan C. Han 5 , Y.C. Loraine Tung 1 , John R. Hodges 4 , F. Lucy Raymond 2 , Stephen O’Rahilly 1 and I. Sadaf Farooqi 1 1 University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge, U.K 2 University Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge, U.K 3 West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, U.K 4 Medical Research Council, Cognition and Brain Sciences Unit, and the Department of Clinical Neurosciences, Addenbrooke’s Hospital, Cambridge, U.K 5 Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland Address correspondence and reprint requests to I. Sadaf Farooqi, University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge, CB2 2XY, U.K. E-mail: isf20{at}cam.ac.uk Abstract The neurotrophin brain-derived neurotrophic factor (BDNF) inhibits food intake, and rodent models of BDNF disruption all exhibit increased food intake and obesity, as well as hyperactivity. We report an 8-year-old girl with hyperphagia and severe obesity, impaired cognitive function, and hyperactivity who harbored a de novo chromosomal inversion, 46,XX,inv(11)(p13p15.3), a region encompassing the BDNF gene. We have identified the proximal inversion breakpoint that lies 850 kb telomeric of the 5′ end of the BDNF gene. The patient’s genomic DNA was heterozygous for a common coding polymorphism in BDNF , but monoallelic expression was seen in peripheral lymphocytes. Serum concentration of BDNF protein was reduced compared with age- and BMI-matched subjects. Haploinsufficiency for BDNF was associated with increased ad libitum food intake, severe early-onset obesity, hyperactivity, and cognitive impairment. These findings provide direct evidence for the role of the neurotrophin BDNF in human energy homeostasis, as well as in cognitive function, memory, and behavior. BAC, bacterial artificial chromosome BDNF, brain-derived neurotrophic factor FISH, fluorescence in situ hybridization TrkB, tropomyosin-related kinase B Footnotes Additional information for this article can be found in an online appendix at http://diabetes.diabetesjournals.org . The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Accepted August 21, 2006. Received April 24, 2006. DIABETES