Details

Autor(en) / Beteiligte

• Wang, Zhifeng (Shanghai Jiaotong University, Shanghai, China)
• Lauwerijssen, Maarten J.C. (Wageningen University, Wageningen, Netherlands)
• Yuan, Jingqi (Shanghai Jiaotong University, Shanghai, China), E-mail: jqyuan@sjtu.edu.cn

Titel

Combined Age and Segregated Kinetic Model for Industrial-scale Penicillin Fed-batch Cultivation

Ist Teil von

• Biotechnology and bioprocess engineering, 2005-04, Vol.10 (2), p.142-148

Ort / Verlag

Dordrecht: Springer Nature B.V

Erscheinungsjahr

2005

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This paper proposes a cell age model for Penicillium chrysogenum fed-batch cultivation to supply a qualitative insight into morphology-associated dynamics. The average ages of the segregated cell populations, such as growing cells, non-growing cells and intact productive cells, were estimated by this model. A combined model was obtained by incorporating the average ages of the cell sub-populations into a known but modified segregated kinetic model from literature. For simulations, no additional effort was needed for parameter identification since the cell age model has no internal parameters.