Details

Autor(en) / Beteiligte

• Atagi, S.
• Imamura, F.
• Yokoyama, A.
• Minato, K.
• Harada, T.
• Katakami, N.
• Yokoyama, T.
• Ohashi, Y.
• Watanabe, K.
• Eguchi, K.

Titel

1586P - QOL and Survival Survey of Cancer Cachexia in Advanced NSCLC Patients - JNUQ-LC Study, TORG0912

Ist Teil von

• Annals of oncology, 2012-09, Vol.23, p.ix511-ix511

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Cancer cachexia, mainly characterized by muscle atrophy and subsequent cancer induced weight loss (CIWL), is attributed to about a third of cancer deaths. Despite worsening prognoses with the symptoms, clinical factors involved and the effect of CIWL to the overall status remain unexplained. We planned a prospective cohort study, Japan Nutrition and QOL survey in patients with advanced NSCLC study to investigate changes in CIWL in relation to grip, QOL, and clinical parameters to understand their effects on prognosis. Untreated stage IV NSCLC patients with ECOG PS of 0-2 were registered. Their body weight (BW), grip, QOL, Karnofsky Performance Scale, biochemical assay, and survival were recorded every four weeks for one year from the start of cancer treatments. Patients were classified by BW loss ≥ 5% and cachexia diagnosis by BW loss, fatigue, anorexia, and abnormal assay results. Estimated survival curves were drawn by Kaplan-Meier method, and Log-rank test was applied. To evaluate the effect of cancer cachexia attribution to QOL, we performed principal component analysis, factor analysis, and analysis on time course data using generalized estimating equation (GEE). Out of 466 patients registered, 406 were evaluable and analyzed. Patient characteristics were: median age: 67 (33-87) years, male/female ratio: 280/126, median BW: 56.5kg, PS 0: 39.2%, and PS 1: 51.5%. The patients with BW loss of ≥ 5% (n = 219) reported more early deaths than those without (n = 166, p < 0.0001). Patients with cachexia (n = 169) reported more early deaths than those without (n = 216, p < 0.0001). All correlations between principal component scores estimated from the variables considered the signs of cancer cachexia (cancer cachexia attributions: more weight on anorexia, fatigue, BW and grip) and each factor scores of QOL domains estimated from QOL factor analyses were significant (p < 0.01). From the time course data analyses using GEE, cancer cachexia attributions of each visit are shown as useful variables for all QOL domains (p < 0.01). Cancer cachexia decreased QOL and possibly affected prognoses. Cachexia preventions and treatments based on the further elucidation of its pathology are needed. All authors have declared no conflicts of interest.