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Hub promiscuity in protein-protein interaction networks
Ist Teil von
International Journal of Molecular Sciences, 2010-04, Vol.11 (4), p.1930-1943
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2010
Link zum Volltext
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last few years, the structural properties of hubs have been extensively studied. We review the currently known features that are particular to hubs, possibly affecting their binding ability. Specifically, we look at the levels of intrinsic disorder, surface charge and domain distribution in hubs, as compared to non-hubs, along with differences in their functional domains.